Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD...
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The NLR gene family mediates host immunity to various acute pathogenic stimuli, but its role in chronic infection is not known. This paper addressed the role of NLRP3 (NALP3), its adaptor protein PYCARD (ASC), and caspase-1 during infection with Mycobacterium tuberculosis (Mtb). Mtb infection of macrophages in culture induced IL-1beta secretion, an...
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Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
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TN_cdi_plos_journals_1318936082
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1318936082
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0012320
