Sharpin contributes to TNFα dependent NFκB activation and anti-apoptotic signalling in hepatocytes
Sharpin contributes to TNFα dependent NFκB activation and anti-apoptotic signalling in hepatocytes
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
TNFα stimulates both pro- and anti-apoptotic signalling in hepatocytes. Anti-apoptotic signalling depends on a cascade of ubiquitylation steps leading to NFκB activation. Using Sharpin-deficient mice, we show that the ubiquitin binding protein Sharpin interacts with Hoip, an E3 ligase which generates linear ubiquitin chains. Sharpin-deficiency sens...
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Full title
Sharpin contributes to TNFα dependent NFκB activation and anti-apoptotic signalling in hepatocytes
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TN_cdi_plos_journals_1322478083
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1322478083
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0029993
