A model for how signal duration can determine distinct outcomes of gene transcription programs
A model for how signal duration can determine distinct outcomes of gene transcription programs
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood. It is known that IL-6 induces a transient STAT3 signal and that IL-10 induces a sustained STAT3 signal due to the STAT3-induced inhibitor SOCS3's...
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Full title
A model for how signal duration can determine distinct outcomes of gene transcription programs
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TN_cdi_plos_journals_1323994035
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1323994035
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0033018
