PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis
PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
PTPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) confers the highest risk of rheumatoid arthritis among non-HLA genetic variations that are known to be associated with this dise...
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Full title
PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis
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TN_cdi_plos_journals_1323994651
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1323994651
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0033067
