Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encep...
Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis
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Author / Creator
Zhou, Weisong , Dowell, Dustin R , Huckabee, Matthew M , Newcomb, Dawn C , Boswell, Madison G , Goleniewska, Kasia , Lotz, Matthew T , Toki, Shinji , Yin, Huiyong , Yao, Songyi , Natarajan, Chandramohan , Wu, Pingsheng , Sriram, Subramaniam , Breyer, Richard M , Fitzgerald, Garret A and Peebles, Jr, R Stokes
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Prostaglandin I(2) (PGI(2)), a lipid mediator currently used in treatment of human disease, is a critical regulator of adaptive immune responses. Although PGI(2) signaling suppressed Th1 and Th2 immune responses, the role of PGI(2) in Th17 differentiation is not known.
In mouse CD4(+)CD62L(+) naïve T cell culture, the PGI(2) analogs iloprost and...
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Full title
Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis
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TN_cdi_plos_journals_1324610939
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1324610939
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0033518
