The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocri...
The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The chemokine receptor CXCR4 and ligand SDF-1α are expressed in fetal and adult mouse islets. Neutralization of CXCR4 has previously been shown to diminish ductal cell proliferation and increase apoptosis in the IFNγ transgenic mouse model in which the adult mouse pancreas displays islet regeneration. Here, we demonstrate that CXCR4 and SDF-1α are...
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The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells
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TN_cdi_plos_journals_1325027723
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1325027723
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0038721
