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The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocri...

The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocri...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1325027723

The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells

About this item

Full title

The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells

Publisher

United States: Public Library of Science

Journal title

PloS one, 2012-06, Vol.7 (6), p.e38721-e38721

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The chemokine receptor CXCR4 and ligand SDF-1α are expressed in fetal and adult mouse islets. Neutralization of CXCR4 has previously been shown to diminish ductal cell proliferation and increase apoptosis in the IFNγ transgenic mouse model in which the adult mouse pancreas displays islet regeneration. Here, we demonstrate that CXCR4 and SDF-1α are...

Alternative Titles

Full title

The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1325027723

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1325027723

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0038721

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