Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium h...
Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. Regulation of calcium handling in beta-cells remains incompletely understood. Gem, a member of the RGK (Rad/Gem/Kir) family regulates calcium channel handling in other cell types, and G...
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Full title
Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling
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TN_cdi_plos_journals_1325028263
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1325028263
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0039462
