A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease
A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The β site APP cleaving enzyme 1 (BACE1) is the rate-limiting β-secretase enzyme in the amyloidogenic processing of APP and Aβ formation, and therefore it has a prominent role in Alzheimer's disease (AD) pathology. Recent evidence suggests that the prion protein (PrP) interacts directly with BACE1 regulating its β-secretase activity. Moreover, PrP...
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Full title
A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease
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TN_cdi_plos_journals_1326503618
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326503618
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0043926
