The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for vir...
The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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During the process of HIV-1 fusion with the target cell, the N-terminal heptad repeat (NHR) of gp41 interacts with the C-terminal heptad repeat (CHR) to form fusogenic six-helix bundle (6-HB) core. We previously identified a crucial residue for 6-HB formation and virus entry--Lys63 (K63) in the C-terminal region of NHR (aa 54-70), which forms a hyd...
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Full title
The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry
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TN_cdi_plos_journals_1326546315
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326546315
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0044874
