Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism
Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The iminosugar N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of glycosphingolipid (GSL) biosynthesis is known to ameliorate diabetes, insulin sensitivity and to prevent liver steatosis in ob/ob mice. Thus far the effect of GSL synthesis inhibition on pre-existing NASH has not yet been assessed. To investigate it...
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Full title
Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism
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TN_cdi_plos_journals_1326551779
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326551779
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0038520
