Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend l...
Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolu...
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Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila
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TN_cdi_plos_journals_1326560410
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326560410
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0047699
