Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content
Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Alterations in lipid homeostasis are implicated in several neurodegenerative diseases, although the mechanisms responsible are poorly understood. We evaluated the impact of cholesterol accumulation, induced by U18666A, quinacrine or mutations in the cholesterol transporting Niemann-Pick disease type C1 (NPC1) protein, on lysosomal stability and sen...
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Full title
Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content
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TN_cdi_plos_journals_1326746276
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326746276
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0050262
