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Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced...

Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326749106

Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in mice

About this item

Full title

Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in mice

Publisher

United States: Public Library of Science

Journal title

PloS one, 2012-11, Vol.7 (11), p.e50187

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Both acquired and inherited genetic factors contribute to excessive alcohol consumption and the corresponding development of addiction. Here we show that the genetic deficiency in neprilysin [NEP] did not change the kinetics of alcohol degradation but led to an increase in alcohol intake in mice in a 2-bottle-free-choice paradigm after one single s...

Alternative Titles

Full title

Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1326749106

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326749106

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0050187

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