Log in to save to my catalogue
Log in to save to my catalogue

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6

| Ask | Become a Library member

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326752034

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6

About this item

Publication information

Publisher

United States: Public Library of Science

Subjects

More information

Scope and Contents

Contents

Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase-6 that acts by an uncompetitive binding mode that is an unprecedented mechanism of inhibition again...

Alternative Titles

Full title

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1326752034

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326752034

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0050864

How to access this item

Log in as a Library member

View record in Gale

About resource

About resource

View in old catalogue

Connecting people and collections