NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of th...
NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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We demonstrate that during inflammatory responses the nuclear factor kappa B (NF-κB) induces the synthesis of melatonin by macrophages and that macrophage-synthesized melatonin modulates the function of these professional phagocytes in an autocrine manner. Expression of a DsRed2 fluorescent reporter driven by regions of the aa-nat promoter, that en...
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Full title
NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene
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TN_cdi_plos_journals_1327147016
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1327147016
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0052010
