Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enh...
Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that bind to and are activated by collagens. Similar to collagen-binding β1 integrins, the DDRs bind to specific motifs within the collagen triple helix. However, these two types of collagen receptors recognize distinct collagen sequences. While GVMGFO (O is hydroxyproline...
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Full title
Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation
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TN_cdi_plos_journals_1327176355
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1327176355
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0052209
