Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume
Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume
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United States: Public Library of Science
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English
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United States: Public Library of Science
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We have engineered a transgenic mouse on a C57BL/6 background that bears a floxed Itga2 gene. The crossing of this mouse strain to transgenic mice expressing Cre recombinase driven by the megakaryocyte (MK)-specific Pf4 promoter permits the conditional knockout of Itga2 in the MK/platelet lineage. Mice lacking MK α2β1 develop normally, are fertile,...
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Full title
Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume
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TN_cdi_plos_journals_1327940927
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1327940927
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0055094
