Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures
Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na(+)-K(+)-2 Cl(-) cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABAA receptors in the perinatal period. The most common cause of neonatal seizures is hypoxic encephalop...
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Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures
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TN_cdi_plos_journals_1330895040
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1330895040
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0057148
