Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: i...
Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Germline deletion of Jak2 in mice results in embryonic lethality at E12.5 due to impaired hematopoiesis. However, the role that Jak2 might play in late gestation and postnatal life is unknown. To understand this, we utilized a conditional knockout approach that allowed for the deletion of Jak2 at various stages of prenatal and postnatal life. Speci...
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Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans
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TN_cdi_plos_journals_1330899210
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1330899210
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1932-6203
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1932-6203
DOI
10.1371/journal.pone.0059675
