Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screenin...
Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening
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Author / Creator
Jia, JianMin , Xu, XiaoLi , Liu, Fang , Guo, XiaoKe , Zhang, MingYe , Lu, MengChen , Xu, LiLi , Wei, JinLian , Zhu, Jia , Zhang, ShengLie , Zhang, ShengMiao , Sun, HaoPeng and You, QiDong
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
Heat shock protein 90 (Hsp90), whose inhibitors have shown promising activity in clinical trials, is an attractive anticancer target. In this work, we first explored the significant pharmacophore features needed for Hsp90 inhibitors by generating a 3D-QSAR pharmacophore model. It was then used to virtually screen the SPECS databases, identifying 17...
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Full title
Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening
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TN_cdi_plos_journals_1330900694
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1330900694
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0059315
