HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxy...
HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Cellular adaptation to hypoxic conditions mainly involves transcriptional changes in which hypoxia inducible factors (HIFs) play a critical role. Under hypoxic conditions, HIF protein is stabilized due to inhibition of the activity of prolyl hydroxylases (EGLNs). Because the reaction carried out by these enzymes uses oxygen as a co-substrate it is...
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HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia
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TN_cdi_plos_journals_1332948403
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1332948403
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0030470
