Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Le...
Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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We explored the possibility to target Ewing's sarcoma family of tumors (ESFT) by redirecting T cells. To this aim, we considered NKG2D-ligands (NKG2D-Ls) as possible target antigens. Detailed analysis of the expression of MICA, MICB, ULBP-1, -2, and -3 in fourteen ESFT cell lines revealed consistent expression of at least one NKG2D-L. Thus, for red...
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Full title
Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection
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TN_cdi_plos_journals_1332950391
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1332950391
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0031210
