Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral s...
Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis
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Author / Creator
Northeast ALS Consortium , for the Northeast ALS Consortium , Berry, James D , Shefner, Jeremy M , Conwit, Robin , Schoenfeld, David , Keroack, Myles , Felsenstein, Donna , Krivickas, Lisa , David, William S , Vriesendorp, Francine , Pestronk, Alan , Caress, James B , Katz, Jonathan , Simpson, Ericka , Rosenfeld, Jeffrey , Pascuzzi, Robert , Glass, Jonathan , Rezania, Kourosh , Rothstein, Jeffrey D , Greenblatt, David J and Cudkowicz, Merit E
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Ceftriaxone increases expression of the astrocytic glutamate transporter, EAAT2, which might protect from glutamate-mediated excitotoxicity. A trial using a novel three stage nonstop design, incorporating Phases I-III, tested ceftriaxone in ALS. Stage 1 determined the cerebrospinal fluid pharmacokinetics of ceftriaxone in subjects with ALS. Stage 2...
Alternative Titles
Full title
Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis
Authors, Artists and Contributors
Author / Creator
for the Northeast ALS Consortium
Berry, James D
Shefner, Jeremy M
Conwit, Robin
Schoenfeld, David
Keroack, Myles
Felsenstein, Donna
Krivickas, Lisa
David, William S
Vriesendorp, Francine
Pestronk, Alan
Caress, James B
Katz, Jonathan
Simpson, Ericka
Rosenfeld, Jeffrey
Pascuzzi, Robert
Glass, Jonathan
Rezania, Kourosh
Rothstein, Jeffrey D
Greenblatt, David J
Cudkowicz, Merit E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1343544827
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1343544827
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0061177
