Valproic acid downregulates RBP4 and elicits hypervitaminosis A-teratogenesis--a kinetic analysis on...
Valproic acid downregulates RBP4 and elicits hypervitaminosis A-teratogenesis--a kinetic analysis on retinol/retinoic acid homeostatic system
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Valproic acid (VPA) is an antiepileptic and anti-migraine prophylactic drug. VPA exhibits two severe side effects, namely acute liver toxicity and teratogenicity. These side effects are usually seen at the genetic and somatic levels. The cited action mechanisms involve inhibition of histone deacetylase, hypofolatenemia, hyperhomocysteinemia, and re...
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Full title
Valproic acid downregulates RBP4 and elicits hypervitaminosis A-teratogenesis--a kinetic analysis on retinol/retinoic acid homeostatic system
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TN_cdi_plos_journals_1344576417
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1344576417
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0043692
