Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following...
Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular mechanisms governing this cytotoxicity and spread are poorly characterized. Recent studies of viruses a...
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Full title
Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis
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TN_cdi_plos_journals_1346593066
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1346593066
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0062143
