Prevalence and clinical course in invasive infections with meningococcal endotoxin variants
Prevalence and clinical course in invasive infections with meningococcal endotoxin variants
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Meningococci produce a penta-acylated instead of hexa-acylated lipid A when their lpxL1 gene is inactivated. Meningococcal strains with such lipid A endotoxin variants have been found previously in adult meningitis patients, where they caused less blood coagulopathy because of decreased TLR4 activation.
A cohort of 448 isolates from patients wit...
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Full title
Prevalence and clinical course in invasive infections with meningococcal endotoxin variants
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TN_cdi_plos_journals_1350909603
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1350909603
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0049295
