Hsp40 gene therapy exerts therapeutic effects on polyglutamine disease mice via a non-cell autonomou...
Hsp40 gene therapy exerts therapeutic effects on polyglutamine disease mice via a non-cell autonomous mechanism
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The polyglutamine (polyQ) diseases such as Huntington's disease (HD), are neurodegenerative diseases caused by proteins with an expanded polyQ stretch, which misfold and aggregate, and eventually accumulate as inclusion bodies within neurons. Molecules that inhibit polyQ protein misfolding/aggregation, such as Polyglutamine Binding Peptide 1 (QBP1)...
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Hsp40 gene therapy exerts therapeutic effects on polyglutamine disease mice via a non-cell autonomous mechanism
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TN_cdi_plos_journals_1351053073
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1351053073
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0051069
