PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased...
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Author / Creator
Holst, Birgitte , Madsen, Kenneth L , Jansen, Anna M , Jin, Chunyu , Rickhag, Mattias , Lund, Viktor K , Jensen, Morten , Bhatia, Vikram , Sørensen, Gunnar , Madsen, Andreas N , Xue, Zhichao , Møller, Siri K , Woldbye, David , Qvortrup, Klaus , Huganir, Richard , Stamou, Dimitrios , Kjærulff, Ole and Gether, Ulrik
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their subsequent maturation remain unclear. Here, we identify the lipid binding BAR (Bin/amphiphysin/...
Alternative Titles
Full title
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Record Identifier
TN_cdi_plos_journals_1351881985
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1351881985
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1001542
