Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diver...
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases
About this item
Full title
Author / Creator
Ferreira, Ricardo C. , Freitag, Daniel F. , Cutler, Antony J. , Howson, Joanna M. M. , Rainbow, Daniel B. , Smyth, Deborah J. , Kaptoge, Stephen , Clarke, Pamela , Boreham, Charlotte , Coulson, Richard M. , Pekalski, Marcin L. , Chen, Wei-Min , Onengut-Gumuscu, Suna , Rich, Stephen S. , Butterworth, Adam S. , Malarstig, Anders , Danesh, John and Todd, John A.
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, is implicated in the etiology of several chronic diseases. Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary...
Alternative Titles
Full title
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases
Authors, Artists and Contributors
Author / Creator
Freitag, Daniel F.
Cutler, Antony J.
Howson, Joanna M. M.
Rainbow, Daniel B.
Smyth, Deborah J.
Kaptoge, Stephen
Clarke, Pamela
Boreham, Charlotte
Coulson, Richard M.
Pekalski, Marcin L.
Chen, Wei-Min
Onengut-Gumuscu, Suna
Rich, Stephen S.
Butterworth, Adam S.
Malarstig, Anders
Danesh, John
Todd, John A.
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1351901764
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1351901764
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1003444
