Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investiga...
Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Mice cannot be used to evaluate HIV-1 therapeutics and vaccines because they are not infectible by HIV-1 due to structural differences between several human and mouse proteins required for HIV-1 entry and replication including CD4, CCR5 and cyclin T1. We overcame this limitation by constructing mice with CD4 enhancer/promoter-regulated human CD4, C...
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Full title
Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy
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TN_cdi_plos_journals_1351912089
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1351912089
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0063537
