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LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease...

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LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1364760736

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD)

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United States: Public Library of Science

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Contents

Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3) and resides at the linkage peak for late-onset Alzheimer's disease (LOAD) risk and plasma amyloid β (Aβ) levels. In-vitro knock-down of LRRTM3 was previously shown to decrease secreted Aβ, although the mec...

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LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD)

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Record Identifier

TN_cdi_plos_journals_1364760736

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1364760736

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ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0064164

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