Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced...
Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxicity. Herein, we hypothesize that TLR3 activation significantly contributed to APAP-induced liver injury. In fasted wildtype (WT) mice, APAP caused significant cellular necrosis, edema, and inflammation in the liver, and the de novo expression and acti...
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Full title
Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity
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TN_cdi_plos_journals_1365788422
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1365788422
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0065899
