Cell surface-bound TIMP3 induces apoptosis in mesenchymal Cal78 cells through ligand-independent act...
Cell surface-bound TIMP3 induces apoptosis in mesenchymal Cal78 cells through ligand-independent activation of death receptor signaling and blockade of survival pathways
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The matrix metalloproteinases (MMPs) and their endogenous regulators, the tissue inhibitor of metalloproteinases (TIMPs 1-4) are responsible for the physiological remodeling of the extracellular matrix (ECM). Among all TIMPs, TIMP3 appears to play a unique role since TIMP3 is a secreted protein and, unlike the other TIMP family members, is tightly...
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Full title
Cell surface-bound TIMP3 induces apoptosis in mesenchymal Cal78 cells through ligand-independent activation of death receptor signaling and blockade of survival pathways
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TN_cdi_plos_journals_1427374658
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1427374658
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0070709
