Pharmacological reversal of histone methylation presensitizes pancreatic cancer cells to nucleoside...
Pharmacological reversal of histone methylation presensitizes pancreatic cancer cells to nucleoside drugs: in vitro optimization and novel nanoparticle delivery studies
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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We evaluated the potential of an investigational histone methylation reversal agent, 3-deazaneplanocin A (DZNep), in improving the chemosensitivity of pancreatic cancer to nucleoside analogs (i.e., gemcitabine). DZNep brought delayed but selective cytotoxicity to pancreatic cancer cells without affecting normal human pancreatic ductal epithelial (H...
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Full title
Pharmacological reversal of histone methylation presensitizes pancreatic cancer cells to nucleoside drugs: in vitro optimization and novel nanoparticle delivery studies
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TN_cdi_plos_journals_1430248695
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1430248695
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0071196
