Soluble variants of human recombinant glutaminyl cyclase
Soluble variants of human recombinant glutaminyl cyclase
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Recombinant human Glutaminyl Cyclase expressed in E. coli is produced as inclusion bodies. Lack of glycosylation is the main origin of its accumulation in insoluble aggregates. Mutation of single isolated hydrophobic amino acids into negative amino acids was not able to circumvent inclusion bodies formation. On the contrary, substitution with carbo...
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Soluble variants of human recombinant glutaminyl cyclase
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TN_cdi_plos_journals_1430436697
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1430436697
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0071657