The toll-like receptor agonist imiquimod is active against prions
The toll-like receptor agonist imiquimod is active against prions
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Using a yeast-based assay, a previously unsuspected antiprion activity was found for imiquimod (IQ), a potent Toll-like receptor 7 (TLR7) agonist already used for clinical applications. The antiprion activity of IQ was first detected against yeast prions [PSI (+) ] and [URE3], and then against mammalian prion both ex vivo in a cell-based assay and...
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Full title
The toll-like receptor agonist imiquimod is active against prions
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TN_cdi_plos_journals_1430787554
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1430787554
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0072112
