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Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and S...

Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and S...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1440997897

Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells

About this item

Full title

Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells

Publisher

United States: Public Library of Science

Journal title

PloS one, 2013-07, Vol.8 (7), p.e69585

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Proinflammatory cytokines secreted from microglia are known to induce a secondary immune response in astrocytes leading to an inflammatory loop. Cytokines also interfere with neurogenesis during aging and in neurodegenerative diseases. The present study examined the mechanism of induction of inflammatory mediators at the transcriptional level in hu...

Alternative Titles

Full title

Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1440997897

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1440997897

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0069585

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