Exploring early stages of the chemical unfolding of proteins at the proteome scale
Exploring early stages of the chemical unfolding of proteins at the proteome scale
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United States: Public Library of Science
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English
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United States: Public Library of Science
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After decades of using urea as denaturant, the kinetic role of this molecule in the unfolding process is still undefined: does urea actively induce protein unfolding or passively stabilize the unfolded state? By analyzing a set of 30 proteins (representative of all native folds) through extensive molecular dynamics simulations in denaturant (using...
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Exploring early stages of the chemical unfolding of proteins at the proteome scale
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TN_cdi_plos_journals_1477947642
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1477947642
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1003393