Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locu...
Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Slipped-strand DNAs, formed by out-of-register mispairing of repeat units on complementary strands, were proposed over 55 years ago as transient intermediates in repeat length mutations, hypothesized to cause at least 40 neurodegenerative diseases. While slipped-DNAs have been characterized in vitro, evidence of slipped-DNAs at an endogenous locus...
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Full title
Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues
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TN_cdi_plos_journals_1477954103
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1477954103
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1003866
