O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function
O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Fucosylation of Epidermal Growth Factor-like (EGF) repeats by protein O-fucosyltransferase 1 (POFUT1 in vertebrates, OFUT1 in Drosophila) is pivotal for NOTCH function. In Drosophila OFUT1 also acts as chaperone for Notch independent from its enzymatic activity. NOTCH ligands are also substrates for POFUT1, but in Drosophila OFUT1 is not essential...
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Full title
O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function
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TN_cdi_plos_journals_1497395727
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1497395727
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0088571
