Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci
Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci
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Author / Creator
Service, Susan K , Teslovich, Tanya M , Fuchsberger, Christian , Ramensky, Vasily , Yajnik, Pranav , Koboldt, Daniel C , Larson, David E , Zhang, Qunyuan , Lin, Ling , Welch, Ryan , Ding, Li , McLellan, Michael D , O'Laughlin, Michele , Fronick, Catrina , Fulton, Lucinda L , Magrini, Vincent , Swift, Amy , Elliott, Paul , Jarvelin, Marjo-Riitta , Kaakinen, Marika , McCarthy, Mark I , Peltonen, Leena , Pouta, Anneli , Bonnycastle, Lori L , Collins, Francis S , Narisu, Narisu , Stringham, Heather M , Tuomilehto, Jaakko , Ripatti, Samuli , Fulton, Robert S , Sabatti, Chiara , Wilson, Richard K , Boehnke, Michael and Freimer, Nelson B
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
Genome-wide association studies (GWAS) have identified >500 common variants associated with quantitative metabolic traits, but in aggregate such variants explain at most 20-30% of the heritable component of population variation in these traits. To further investigate the impact of genotypic variation on metabolic traits, we conducted re-sequencing...
Alternative Titles
Full title
Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci
Authors, Artists and Contributors
Author / Creator
Teslovich, Tanya M
Fuchsberger, Christian
Ramensky, Vasily
Yajnik, Pranav
Koboldt, Daniel C
Larson, David E
Zhang, Qunyuan
Lin, Ling
Welch, Ryan
Ding, Li
McLellan, Michael D
O'Laughlin, Michele
Fronick, Catrina
Fulton, Lucinda L
Magrini, Vincent
Swift, Amy
Elliott, Paul
Jarvelin, Marjo-Riitta
Kaakinen, Marika
McCarthy, Mark I
Peltonen, Leena
Pouta, Anneli
Bonnycastle, Lori L
Collins, Francis S
Narisu, Narisu
Stringham, Heather M
Tuomilehto, Jaakko
Ripatti, Samuli
Fulton, Robert S
Sabatti, Chiara
Wilson, Richard K
Boehnke, Michael
Freimer, Nelson B
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1498391551
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1498391551
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1004147
