Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its...
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin (Ig) heavy-chain (hIGH), kappa-chain (hIGK), and lambda-chain (hIGL) germline loci produced physi...
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Full title
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production
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TN_cdi_plos_journals_1504771873
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1504771873
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0090383
