Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottlene...
Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Retroviral insertional mutagenesis (RIM) is a powerful tool for cancer genomics that was combined in this study with deep sequencing (RIM/DS) to facilitate a comprehensive analysis of lymphoma progression. Transgenic mice expressing two potent collaborating oncogenes in the germ line (CD2-MYC, -Runx2) develop rapid onset tumours that can be acceler...
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Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis
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TN_cdi_plos_journals_1507833956
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1507833956
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1004167
