Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear fact...
Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell lines occur at a much lower level than their corresponding activities in primary hepatocytes, and thus these cell lines may not accurately predict dr...
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Full title
Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha
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TN_cdi_plos_journals_1516461437
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1516461437
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0094885
