TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo
TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Mammalian thyroid hormone receptors (TRs) have multiple isoforms, including the bona fide receptors that bind T3 (TRα1, TRβ1 and TRβ2) and a non-hormone-binding variant, TRα2. Intriguingly, TRα2 is strongly expressed in the brain, where its mRNA levels exceed those of functional TRs. Ablation of TRα2 in mice results in over-expression of TRα1, and...
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Full title
TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo
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TN_cdi_plos_journals_1517611058
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1517611058
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0095064
