Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO
Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The protein Keap1 is central to the regulation of the Nrf2-mediated cytoprotective response, and is increasingly recognized as an important target for therapeutic intervention in a range of diseases involving excessive oxidative stress and inflammation. The BTB domain of Keap1 plays key roles in sensing environmental electrophiles and in mediating...
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Full title
Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO
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TN_cdi_plos_journals_1532653323
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1532653323
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0098896
