Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses incl...
Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Coronaviruses raise serious concerns as emerging zoonotic viruses without specific antiviral drugs available. Here we screened a collection of 16671 diverse compounds for anti-human coronavirus 229E activity and identified an inhibitor, designated K22, that specifically targets membrane-bound coronaviral RNA synthesis. K22 exerts most potent antivi...
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Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus
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TN_cdi_plos_journals_1536045750
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1536045750
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1004166
