Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification
Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification
About this item
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Author / Creator
Ruckenstuhl, Christoph , Netzberger, Christine , Entfellner, Iryna , Carmona-Gutierrez, Didac , Kickenweiz, Thomas , Stekovic, Slaven , Gleixner, Christina , Schmid, Christian , Klug, Lisa , Sorgo, Alice G , Eisenberg, Tobias , Büttner, Sabrina , Mariño, Guillermo , Koziel, Rafal , Jansen-Dürr, Pidder , Fröhlich, Kai-Uwe , Kroemer, Guido and Madeo, Frank
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
Reduced supply of the amino acid methionine increases longevity across species through an as yet elusive mechanism. Here, we report that methionine restriction (MetR) extends yeast chronological lifespan in an autophagy-dependent manner. Single deletion of several genes essential for autophagy (ATG5, ATG7 or ATG8) fully abolished the longevity-enha...
Alternative Titles
Full title
Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification
Authors, Artists and Contributors
Author / Creator
Netzberger, Christine
Entfellner, Iryna
Carmona-Gutierrez, Didac
Kickenweiz, Thomas
Stekovic, Slaven
Gleixner, Christina
Schmid, Christian
Klug, Lisa
Sorgo, Alice G
Eisenberg, Tobias
Büttner, Sabrina
Mariño, Guillermo
Koziel, Rafal
Jansen-Dürr, Pidder
Fröhlich, Kai-Uwe
Kroemer, Guido
Madeo, Frank
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1536053432
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1536053432
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1004347
