A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by hi...
A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel widely expressed in skin tissues, and peripheral sensory nerve fibres. Activation of TRPV1 releases neuropeptides; the resulting neurogenic inflammation is believed to contribute to the development of pruritus. A TRPV1 antagonist has the potential to perform as...
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Full title
A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers
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TN_cdi_plos_journals_1547308152
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1547308152
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0100610
