Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of...
Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG) of the gene encoding the ubiquitous transcription-factor nuclear-factor-κB (NF-κB) which binds to recogni...
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Full title
Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock
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TN_cdi_plos_journals_1554274734
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1554274734
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0104953
